{"id":1745,"date":"2025-04-09T15:20:55","date_gmt":"2025-04-09T14:20:55","guid":{"rendered":"https:\/\/blogs.manchester.ac.uk\/bsrbr-blog\/?p=1745"},"modified":"2025-04-09T15:20:55","modified_gmt":"2025-04-09T14:20:55","slug":"celebrate-your-registers-collaboration-collaboration-with-international-research-groups","status":"publish","type":"post","link":"https:\/\/blogs.manchester.ac.uk\/bsrbr-blog\/2025\/04\/09\/celebrate-your-registers-collaboration-collaboration-with-international-research-groups\/","title":{"rendered":"Celebrate your registers! Collaboration: Collaboration with international research groups"},"content":{"rendered":"

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The BSRBR-RA is fortunate to be able to collaborate with numerous different research groups both across the UK and internationally.\u00a0<\/span>\u00a0<\/span><\/h2>\n

As part of the <\/span>JAK-pot<\/span><\/b> collaboration, 19 registers internationally \u2013 including the British Society for Rheumatology Biologics Register for RA (BSRBR-RA), collated all their data on how well these drugs work in the real-world. Overall, more than 30,000 different episodes of treatment were included. It is the first to evaluate real-life effectiveness and safety outcomes among four common available advanced treatment options; TNF inhibitors, IL6 inhibitors, abatacept, and JAK inhibitors.\u00a0<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

\"AOverall, how long patients remained on treatment for (a marker for how well the drug works for) was similar between treatments. This was also true of\u00a0how many patients responded to treatment. However, more patients stopped JAK inhibitors for safety reasons. This could be due to a combination of real differences in safety profile as well as heightened concerns from physicians and patients, causing them potentially to be more careful with this newer treatment.\u00a0<\/span>\u00a0<\/span><\/p>\n

Thus, these results support the use of these four treatments for treating patients with RA in \u2018real-world\u2019 clinical care. Considering similar effectiveness among these treatments, this study calls for the evaluation of other outcomes that could influence treatment choice, such as patient-reported outcomes, comorbidities, tolerability, safety or cost-effectiveness.\u00a0<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

For those interested in the full research, it can be found <\/span>here<\/span><\/a><\/p>\n

More information:\u00a0<\/h3>\n

Support your registers! click <\/span>here<\/span><\/a> for further information<\/span>\u00a0<\/span><\/p>\n

Contact us – <\/span>biologics.register@manchester.ac.uk<\/span><\/a>\u00a0<\/span><\/p>\n

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Related<\/h1>\n

Related posts:<\/h3>
<\/div>
<\/div>
<\/div>

Participant Data Journey -what happens to the data?<\/h2><\/div><\/div><\/a>
<\/div>

Celebrating our BSRBR-RA sites<\/h2><\/div><\/div><\/a>
<\/div>

Read about some of the recent research from that BSRBR-RA looking at biosimilars.<\/h2><\/div><\/div><\/a><\/div>
<\/div><\/div><\/div>\n

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+44 (0) 161 306 6000<\/p>\n

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The University of Manchester
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