Capture Hi-C and novel candidate genes

by Web team (HR) | Feb 8, 2019 | Rheumatoid arthritis

Musculoskeletal research findings What was already known? Autoimmune diseases, such as rheumatoid arthritis and type 1 diabetes, have a strong genetic element. Differences in people’s DNA, which makes up the genetics of each cell, can put them at an increased...

The effect of different types of insoles or shoe modifications on people with medial knee osteoarthritis

by Web team (HR) | Feb 8, 2019 | Osteoarthritis

Musculoskeletal research findings Background This was a randomised clinical trial assessing different shoes and insoles which have been used in attempting to reduce the loads in the knee in individuals with medial knee osteoarthritis. Increased biomechanical loads in...

Identifying risk factors that can differentiate PsA from skin-only psoriasis

by Web team (HR) | Feb 8, 2019 | Psoriatic arthritis

Musculoskeletal research findings What was already known? Psoriatic arthritis (PsA) is an inflammatory condition causing pain and stiffness in joints and tendons. Approximately one third of patients with psoriasis will go on to develop PsA resulting in a reduction in...

Key insights into the genetics of PsA that explain fundamental differences between psoriasis and PsA.

by Web team (HR) | Feb 8, 2019 | Psoriatic arthritis

Musculoskeletal research findings What was already known? Psoriatic arthritis (PsA) is an inflammatory condition causing pain and stiffness in joints and tendons. Approximately one third of patients with psoriasis will go on to develop PsA resulting in a reduction in...

Chronic widespread pain is associated with worsening frailty in European men

by Web team (HR) | Feb 8, 2019 | Pain and fatigue

Musculoskeletal research findings What was already known? Frailty is a common syndrome that becomes more common with increasing age, with an overall prevalence estimate of 10.7% in community-dwelling older adults. There is no generally accepted definition of frailty;...