**** Just published **** Our latest paper on improving adherence to methotrexate 'Translating research into practice: halving non-adherence to methotrexate', has been awarded one of the first British Society for Rheumatology (BSR) Best Practice awards!!! Here's the...
Category: Rheumatoid arthritis
Chromatin interactions reveal novel gene targets for drug repositioning in rheumatic diseases
Diseases affecting the joints, muscle and bone, (rheumatic diseases), such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) and psoriatic arthritis (PsA) are chronic, disabling conditions that affect millions of people worldwide. These diseases have...
Development and validation of a methotrexate adherence assay
Rheumatoid Arthritis (RA) affects nearly 1% of people in Britain. Most patients with RA experience joint pain, stiffness and swelling. This is due to inflammation of the joints that can lead to joint damage. RA can have a severe impact on the lives of sufferers.RA...
Vaccinations and RA patients on immunosuppressive therapy
What is already known? People with rheumatoid arthritis are at a greater risk of infections than the general population. It is recommended that people with rheumatoid arthritis who are prescribed immunosuppressive medication have yearly influenza and a pneumonia...
20 year outcomes of patients with rheumatoid arthritis
What was already known? Rheumatoid arthritis (RA) is a chronic disease that is associated with joint inflammation. Previous studies have shown that, by 20 years after diagnosis, patients reported severe levels of disability and pain, and the disease was associated...
Tumour necrosis factor inhibitor drugs reduce the occurence of heart attacks
What was already known? Patients with rheumatoid arthritis (RA) are at higher risk of heart attacks (myocardial infarction; MI) than the general population, which is partly explained by the effect of inflammation associated with RA on the blood vessels. There are many...
Drug levels of tumour necrosis factor drugs influence response to treatment
What was already known? Biologic drugs that are used to treat rheumatoid arthritis (RA) act by targeting inflammatory molecules in the body. They are usually very effective but, in about one in five patients where biologics work initially, the treatment stops working...
Missing doses of tumour necrosis factor drugs leads to poorer response rates
What was already known?Anti-TNF drugs (e.g. etanercept, certolizumab, adalimumab and golimumab) are biologic drugs that have radically improved treatment options for patients with Rheumatoid Arthritis (RA). Currently, there are 4 anti-TNF medications available in the...
Gene variants show potential in predicting rheumatoid arthritis disease outcomes
What we found? Arthritis Research UK-funded scientists have identified a new way in which genotyping can be used to predict disease outcomes among sufferers of rheumatoid arthritis. New cohort studies have shown that certain genetic variants are associated with higher...
Capture Hi-C and novel candidate genes
What was already known? Autoimmune diseases, such as rheumatoid arthritis and type 1 diabetes, have a strong genetic element. Differences in people's DNA, which makes up the genetics of each cell, can put them at an increased risk of developing these diseases....
Recent Comments