Keep up to date with recent findings and important advances in our research for musculoskeletal conditions.
Musculoskeletal conditions affect up to 9 million people in the UK.
In the Centre for Musculoskeletal Research, we are dedicated to understanding the causes of these diseases and are researching ways to improve the lives of people living with these conditions.
Find out about the major disease areas we study and the results of our research, below.
The effect of different types of insoles or shoe modifications on people with medial knee osteoarthritis
Background This was a randomised clinical trial assessing different shoes and insoles which have been used in attempting to reduce the loads in the knee in individuals with medial knee osteoarthritis. Increased biomechanical loads in the knee have been associated with...
Identifying risk factors that can differentiate PsA from skin-only psoriasis
What was already known? Psoriatic arthritis (PsA) is an inflammatory condition causing pain and stiffness in joints and tendons. Approximately one third of patients with psoriasis will go on to develop PsA resulting in a reduction in their quality of life caused by...
Key insights into the genetics of PsA that explain fundamental differences between psoriasis and PsA.
What was already known? Psoriatic arthritis (PsA) is an inflammatory condition causing pain and stiffness in joints and tendons. Approximately one third of patients with psoriasis will go on to develop PsA resulting in a reduction in their quality of life caused by...
Chronic widespread pain is associated with worsening frailty in European men
What was already known? Frailty is a common syndrome that becomes more common with increasing age, with an overall prevalence estimate of 10.7% in community-dwelling older adults. There is no generally accepted definition of frailty; one frequently used definition is...
The relationship between psychological distress and multiple tender points across the adult lifespan
What is already known? The rheumatological condition fibromyalgia is characterised by the presence of multiple positive tender points. A positive tender point is a site on the body which is painful on the application of firm pressure. A total of 18 points (in 9 pairs...
Synovial tissue volume: a treatment target in knee osteoarthritis (OA)
What we did? Steroid injections are widely used in managing painful knee osteoarthritis. In this study supported by Arthritis Research UK, men and women aged over 40 with painful knee OA received a steroid injection into their knee joint. Using magnetic resonance...
Patient-preference measures for pain in trials of patients with knee osteoarthritis
What was already known? Pain is an important outcome measure in osteoarthritis (OA) clinical trials. Unfortunately, there is a lack of consensus about what is the best way to measure pain in patients with OA, which means that researchers may try and measure pain in...
Immune-array analysis in sporadic inclusion body myositis
What was already known? Inclusion body myositis (IBM) is a muscle disease that is part of a group of rare autoimmune diseases known as the idiopathic inflammatory myopathies, or myositis. The other major subgroups of myositis are polymyositis, dermatomyositis and...
Have your say on musculoskeletal research
Are you someone who has a musculoskeletal condition, such as rheumatoid arthritis, osteoarthritis, psoriatic arthritis, fibromyalgia or lupus? Are you a carer for someone with a musculoskeletal condition? You can influence world-leading research from the comfort of...
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